E.M.J. (Sabeth) Verpoorte has more than 26 years of research experience in the lab-on-a-chip field, starting in 1990 as a postdoctoral researcher and later as staff research scientist in the pioneering lab-on-a-chip group headed by Professor A. Manz at Ciba Ltd., Basel, Switzerland. In July 1996 she assumed the position of team leader in the group of Professor Nico F. de Rooij at the Institute of Microtechnology (IMT), University of Neuchâtel, Switzerland, where her research interests concentrated on the lab-on-a-chip area for bioanalytical and environmental applications. She successfully led a research team of 5 PhD students and 3 postdocs while at IMT.
Sabeth Verpoorte has been head of the Pharmaceutical Analysis Group in the Groningen Research Institute of Pharmacy, University of Groningen, since 2003. Research in the Pharmaceutical Analysis group is devoted to better understanding micro- and nanofluidic systems and how they can be applied to chemical and cell biological problems. A major driving force for Verpoorte’s research continues to be the acquisition of projects involving scientists from the life sciences, chemical, and physics disciplines, focusing on relevant questions related to drug development and unraveling the underlying mechanisms of disease.
Her present research has taken on a strong cell biological / pharmacological focus, and includes innovative joint projects with colleagues in pharmacokinetics and medical biology on integrated cell and tissue culture and analysis. Ongoing projects involve chip-based human endothelial cell culture and analysis, and the development of organ-on-a-chip systems to study drug metabolism (liver chip, gut chip) and organ interactions (intestine-liver chip). Recent acquisition of national and EU funding have helped expand Verpoorte’s efforts in both these areas. Efforts have also concentrated on continuous-flow particle separation strategies, as well as miniaturized analytical instrumentation (paper spray ionization, multidimensional chromatography). She is or has been involved in several international scientific organizations and journal editorial boards.